Evan Hermel, PhD

Professor, MS in Medical Health Science

ehermel@touro.edu
(707) 638-5241

Biography

I'm a native New Yorker who transplanted to California as one of the founding Faculty of the College of Medicine. I teach basic and clinical Immunology in the COM and the Masters of Science in Medical Health Sciences, as well as Medical Virology. I have two children, 19 and 16 and have been married to the lovely Ruthellen for 24 years and counting.

Education

Ph.D. in Immunology
University of Texas Southwestern Medical Center, Dallas, TX
(Kirsten Fischer Lindahl, advisor)
M.S. in Medical Biology/Immunology
C.W. Post College of Long Island University
Greenvale, NY
B.A. in Biology
Hofstra University
Hempstead, NY

Research

1) Investigating the immunogenicity of Tobacco Mosaic Virus as a novel vaccine candidate (collaboration with Dr. Alison McCormick, College of Pharmacy, Touro University-CA

2) Resurrection of the HLA-H pseudogene

3) Examining cytokine responses to osteopathic manipulative medicine in heart disease patients (collaboration with Dr, Melissa Pearce, College of Medicine, Touro University-CA)

Recent Publications

1. E. Hermel. Caspase-12 and lupus: the curious case of the dog that didn’t bark. 2016. Inflammation & Cell Signaling. e3:1383.

2. E. Hermel. Caspase-12, rheumatoid arthritis, and the dog that didn’t bark. 2016. Immunogenetics Online Access, 1:1-3

3. T. Fuchs, J.A. Kelly, E. Simon, K. L. Sivils and E. Hermel. 2016. The anti-inflammatory CASPASE-12 gene does not influence SLE phenotype in African-Americans. Immunology Letters 173: 21–25

4. L. Marshall, M. Obaidullah, T. Fuchs, N.S. Fineberg, G. Brinkley, T.R. Mikuls, S. L. Bridges Jr. and E. Hermel. 2014. CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics 66:281-5

5. M. Yavari, K.D. Klapstein, W.C. Hartwig, R. Rao, and E. Hermel. 2012. Identification of the functional CASPASE-12 allele in Indian subpopulations. Int. J. Immunogenetics. 39:389-93

6. E. Hermel and K.D. Klapstein. 2011. A possible mechanism for maintenance of the deleterious allele of human CASPASE-12. Med. Hypotheses 77:803–806

7. G. Zhou, D. Wu, E. Balogh, E. Hermel and M. Gochin. 2010. Design, synthesis and evaluation of indole compounds as novel inhibitors targeting gp41. Bioorg. Med. Chem. Lett. 20:1500-1503.

8. J.E. Young, L. Gouw, S. Propp, B.L. Sopher, J. Taylor, A. Lin, E. Hermel, A. Logvinova, S.F. Chen, S. Chen, D.E. Bredesen, R. Truant, L.J. Ptacek, A.R. La Spada, and L.M. Ellerby. 2007. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. J. Biol. Chem. 282:30150-60.

9. E. Hermel, A.J. Hart, I. Gunduz, H. Acton, C. Kim, M. Wurth, S. Uddin, C. Smith, K. Fischer Lindahl and C.J. Aldrich. 2004. Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics. 56:639-49.

10. J. Gafni, E. Hermel, J. Young, C.L. Wellington, R. Siman, M.R. Hayden and L.M. Ellerby. 2004. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. J. Biol. Chem. 279:20211-20.

11. E. Hermel, J.Gafni, S.S. Propp, B.R. Leavitt, C.L. Wellington, J.E. Young, A.S. Hackam, A.V. Logvinova, A.L. Peel, S.F. Chen, V. Hook, R. Singaraja, S.Krajewski, P.C. Goldsmith, H.M. Ellerby, G.S. Salvesen, M.R. Hayden, D.E. Bredesen, and L.M. Ellerby. 2004. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington’s disease. Cell Death Differentiation. 11:424-438.

12. R.V. Rao, A. Peel, A. Logvinova, G. del Rio, E. Hermel, T. Yokota, P.C. Goldsmith, L.M. Ellerby, H.M. Ellerby and D.E. Bredesen. 2002. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Letters 25777:1-7.

13. T. Chun, E. Hermel, H. R. Gaskins, and C.J. Aldrich. 2001. CTL and cDNA sequence analyses of the MHC class Ib molecule Qa1 in nonobese diabetic (NOD) mice. Immunogenetics. 53:506-510.

14. R. Rao, E. Hermel, S. Castro-Obregon, A. Logvinova, G. Del Rio, L. M. Ellerby, P.C. Goldsmith, H.M. Ellerby and D.E. Bredesen. 2001. Coupling endoplasmic reticulum stress to the cell death program: mechanism of caspase activation. J. Biol. Chem. 276:33869-74.

15. E. Hermel, C. Smith and C.J. Aldrich. 2000. Allogeneic responses to the class Ib antigen Qa1: limited TcR Vα but not Vβ chain usage. Immunogenetics. 51:600-605.

16. E. Hermel, A. Hart, R. Miller and C.J. Aldrich. 1999. CTL and sequence analysis of MHC class IB antigens Qa1c (H2-T23r) and Qa1d (H2-T23f). Immunogenetics. 49:712-717.

17. E. Hermel, M. Han, B. Hague, T. Kindt and J.J. Monaco. 1999. Isolation and mapping of the DM genes of rabbit. Implications for the evolution of the DM family. Immunogenetics. 49:295-302.

18. T. Chun, E. Hermel, C.J. Aldrich and H. R. Gaskins. 1999. Porcine LMP7 proteasome subunit cDNA cloning and expression analysis. Immunogenetics. 49:72-77.

19. E. Hermel, E. Grigorenko and C.J. Aldrich. 1997. Increased class Ib antigen display on Tap-2 mutant cells by a mitochondrial function inhibitor. Cell. Immunology. 178:10-15.

20. Kasai, M., K. Hirokawa, K.-I. Kajino, K. Ogasawara, M. Tatsumi, E. Hermel, J.J. Monaco and T. Mizuochi. 1996. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur J Immunol. 26:2101-2107.

21. E. Hermel, J. Yuan and J.J. Monaco. 1995. Characterization of polymorphism within the H2-M MHC class II loci. Immunogenetics. 42:136-142.

22. E. Hermel and J.J. Monaco. 1995. RT1.DMa and RT1.DMb, the rat homologues of H2¬ DMa and H2-DMb. Immunogenetics. 42:446-447.

23. E. Hermel, P. Robinson, J.-X. She and K. Fischer Lindahl. 1993. Sequence divergence of β2-microglobulin alleles of wild Mus musculus and Mus spretus implies positive selection. Immunogenetics. 38:106-116.

24. M. Attaya, S. Jameson, C.K. Martinez, E. Hermel, C. Aldrich, J. Forman, K. Fischer Lindahl, M.J. Bevan & J.J. Monaco. 1992 Ham-2 corrects the class I antigen processing defect in RMA-S cells. Nature. 355:647-649.

25. C.J. Aldrich, R. Waltrip, E. Hermel, M. Attaya, K. Fischer Lindahl, J.J. Monaco and J. Forman. 1992. Cytotoxic T lymphocyte recognition of Qa1b antigens on target cells lacking a functional Tap-2 transporter. J. Immunol. 149:3773.-3777.

26. J.D. Davis, D.H Wilson, E. Hermel, G. Butcher, K. Fischer Lindahl & D.B. Wilson. 1991. Generation of T cells with lytic specificity for atypical antigens. I. A mitochondrial antigen in the rat. J. Exp. Med. 173:823-832.

27. K. Fischer Lindahl, E. Hermel, B.E. Loveland and C.-R. Wang. 1991. The maternally transmitted antigen: A model minor antigen. Annu. Rev. Immunol. 9:351-372.

28. E. Hermel, E. Grigorenko and K. Fischer Lindahl. 1991. Expression of medial class I histocompatibility antigens on RMA-S mutant cells. Int. Immunol. 3:407-412.

29. C.-R. Wang, A. Livingstone, J. Howard, G. Butcher, E. Hermel and K. Fischer Lindahl. 1991. Antigen presentation by neo-classical MHC class I gene products in murine rodents. NATO ASI Series, Vol. H59: Molecular Evolution of the Major Histocompatibility Complex. J. Klein and D. Klein, eds. Springer-Verlag, Berlin. pp 441-462.

30. B. Loveland, C.-R. Wang, H. Yonekawa, E. Hermel, and K. Fischer Lindahl. 1990. Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein. Cell. 60:971-980.

31. J.D. Davis, D.H. Wilson, E. Hermel, G. Butcher, K. Fischer Lindahl and D.B. Wilson. 1990. A maternally-transmitted antigen system in the rat. Transpl. Proc. 22:2547-2548.

32. K. Fischer Lindahl, E. Hermel, B.E. Loveland, S. Richards, C.-R. Wang, and H. Yonekawa. 1989. Molecular definition of a mitochondrially encoded mouse minor histocompatibility antigen. Cold Spring Harbor Symp. Quant. Biol. 56:563-569.