Faculty & Staff at TUC
Shona Mookerjee
College: COM
Department: Basic Sciences
Title: Associate Professor
Phone: (707) 638-5922
Fax: (707) 638-5959
E-Mail: smookerj@touro.edu
Office: Administration & Faculty 1, Rm. 226
B.A., Biology and Environmental Science, Carleton College, 2000
Ph.D., Molecular Genetics, University of Rochester, 2006
Track 2: Pharmaceutical Sciences
Mitochondrial energetics and maintenance
2018 Gunter, A., Gerencser, A.A., Phuong, L., Bornstein, S., Mookerjee, S.A., Maridas, D., Brand, M.D., Rosen, C. Metabolic Programming of Mesenchymal Progenitor
Cells Characterize Lineage Allocation. Journal of Bone and Mineral Research 2018 Jan
17. doi: 10.1002/jbmr.3390. [Epub ahead of print]
2017 Gerencser, A.A*, Mookerjee, S.A*., Jastroch, M., Brand, M.D. Positive Feedback Amplifies the Response of Mitochondrial Membrane Potential
to Glucose Concentration in Clonal Pancreatic Beta Cells. Biochimica et Biophysica
Acta 1863(5): 1054-1065 (doi: 10.1016/j.bbadis.2016.10.015. published online 2016
Oct 20)
*These authors contributed equally
2017 Mookerjee, S.A., Gerencser, A.A., Nicholls, D.G., Brand, M.D. Quantifying intracellular rates of glycolytic
and oxidative ATP production and consumption using extracellular flux measurements.
Journal of Biological Chemistry 292(17): 7189-7207
2017 Nguyen, L., Lucke-Wold, B.P., Mookerjee, S.A., Kaushal, N., Matsumoto, R.R. Sigma-1 receptors and neurodegenerative diseases: Towards
a hypothesis of sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection.
Advances in Experimental Medicine and Biology 964:133-152. doi: 10.1007/978-3-319-50174-1_10.
2016 Gerencser, A.A, Mookerjee, S.A., Jastroch, M., Brand, M.D. Measurement of the Absolute Magnitude and Time Courses
of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells, PLoS
ONE 11(7): e0159199.
2016 Mookerjee, S.A., Nicholls, D.G., Brand, M.D. Determining maximum glycolytic capacity using extracellular
flux measurements. PLoS ONE 11(3): e0152016. doi:10.1371/journal.pone.0152016
2015 Guyenet, S., Mookerjee, S., Lin, A., Custer, S.K., Chen, S.F., Sopher, B.L., LaSpada, A.R., and Ellerby, L.M.Proteolytic
Cleavage of Ataxin-7 Promotes SCA7 Retinal Degeneration and Neurological Dysfunction.
Human Molecular Genetics 2015, 24:3908-3917 (doi: 10.1093/hmg/ddv121. Published online
April 2015)
2015 Mookerjee, S.A., Brand, M.D. Measurement and analysis of extracellular acid production to determine
glycolytic rate. In press, Journal of Visualized Experiments (106), e53464, doi:10.3791/53464
2014 Nguyen, L., Lucke-Wold, B.P., Mookerjee, S.A., Cavendish, J.Z., Robson, M.J., Scadinaro, A.L., Matsumoto, R.R. Role of sigma-1 receptors
in neurodegenerative disease. Journal of Pharmacological Sciences 2015, 127:17-29
(doi:10.1016/j.jphs.2014.12.005; published online December 2014)
2014 Mookerjee, S.A., Goncalves, R.L., Gerencser, A.G., Nicholls, D.G., Brand. M.D. The contributions of
respiration and glycolysis to extracellular acid production. Biochim Biophysica Acta
2015, 1847:171-181 (Published online October 2014, http://dx.doi.org/10.1016/j.bbabio.2014.10.005)
2013 Mookerjee, S.A., Sia, E.A. Using genetic reporters to assess stability and mutation of the yeast mitochondrial
genome. Directed Mutagenesis 2013 ISBN 979-953-307-450-3 InTech Publishing
2011 Mookerjee, S.A., Brand, M.D. Characteristics of the turnover of uncoupling protein 3 by the ubiquitin
proteasome system in isolated mitochondria. Biochim Biophys Acta. 2011. 1807: 1474-81
2010 Brand, M.D., Parker, N., Affourtit, C., Mookerjee, S.A., Azzu, V. Mitochondrial uncoupling protein-2 in pancreatic beta cells. Diabetes Obes
Metab. 2010: Suppl 2:134-40
2010 Mookerjee, S.A., Divakaruni, A., Jastroch, M., Brand, M.D. Mitochondrial uncoupling and lifespan.
Mech Ageing Dev. 2010. 131: 463-72
2010 Jastroch, M., Divakaruni, A., Mookerjee, S., Treberg, J., Brand, M.D. Mitochondrial Proton and Electron Leaks. Essays Biochem.
2010. 47: 53-67
2010 Azzu, V*., Mookerjee, S.A*., Brand, M.D. Rapid Turnover of Mitochondrial Uncoupling Protein 3. Biochem J. 2010.
426: 13-7
*These authors contributed equally
2010 Guyenet, S.J., La Spada, A.R., Mookerjee, S.A., Lin, A., Custer, S.K., Chen, S., Sopher, B.L., Ellerby, L.M. Proteolytic Cleavage
of Ataxin-7 is Required for SCA7 Retinal Degeneration and Neurological Dysfunction"
(Submitted for publication, JN-RM-4725-09)
2009 Mookerjee, S., Papanikolaou, T., Guyenet, S., Sampath, V., Lin, A., Vitelli, C., DeGiacomo, F.,
Sopher, B., Chen, S., La Spada, A., Ellerby, L. Post-translational modification of
ataxin-7 at lysine-257 prevents autophagy-mediated turnover of an N-terminal caspase-7
cleavage fragment" J Neurosci. 2009 29:15134-44
2009 Pogorzala, L., Mookerjee, S.A., Sia, E.A. A role for Msh1p in mitochondrial base excision repair Genetics 2009. 182:
699-709
2006 Mookerjee, S.A., Sia, E.A. Overlapping contributions of Msh1p and putative recombination proteins
Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in
the mitochondrial genome of Saccharomyces cerevisiae. Mutation Research 2006. 595:
91-106
2005 Mookerjee, S.A., Lyon, H., Sia, E.A. Analysis of the functional domains of the mismatch repair homolog,
Msh1p and its role in mitochondrial genome maintenance. Current Genetics 2005. 47:
84-99.
2016-present Member, American Physiological Society
2016-present Member, American Society for Biochemistry and Molecular Biology
2015-present Member, Society for Redox Biology and Medicine
2017 Co-investigator (with Karl Meszaros), Touro-CA IRAP: The effect of fructose on energy metabolism and substrate utilization in liver cells
2016 Co-investigator (with Maggie Louie, lead PI), NIH R15 Award: “Prolonged cadmium exposure promotes oxidative stress-dependent transcription and breast cancer progression” R15ES025917-01A1
2015 Best Professor, College of Pharmacy Class of 2017
2010 California Institute for Regenerative Medicine Research Training Award: “Dynamic regulation of UCP2 in multipotent stem cells” TG2-101155
2009 NIH U54 Pilot Project Award: “Mapping ubiquitination sites of the mitochondrial uncoupling proteins UCP2 and UCP3” under “Mass spectrometry and imaging technologies in Geroscience” 1PL1AG032118-01
2007-2008 NIH T32 Training Award AG000266
2000 SURE Internship award, Gulf of Maine Foundation
1996-2000 James J. Kerrigan Memorial Scholarship, Merck and Co.
Touro University College of Pharmacy
Assistant Professor
Biological and Pharmaceutical Sciences
2013-present
Buck Institute for Research on Aging
Adjunct Assistant Professor
2013-present
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