Faculty & Staff at TUC
Evan Hermel
College: COM
Department: Basic Sciences, MSMHS, Preclinical Education, Research
Title: Professor
Phone: (707) 638-5241
Fax: (707) 638-5255
E-Mail: evan.hermel@tu.edu
Office: Administration & Faculty 1, Rm. 225
| Institution | Degree | Field of Study | Obtained |
| University of Texas Southwestern Medical Center, Dallas, TX | PhD | Immunology | 1992 |
| C.W. Post College of Long Island University, Greenvale, NY | M.S. | Medical Biology/Immunology | 1983 |
| Hofstra University, Hempstead, NY | B.A. | Biology | 1978 |
Teaching experience:
Touro University College of Osteopathic Medicine
Dr Hermel lectures in Basic and Clinical Immunology and Medical Microbiology in the following COM courses:
IS-Fundamentals of Osteopathic Medicine (MED 600)
IS-Central Nervous System/Musculoskeletal (MED 604)
IS-Cardiovascular/Respiratory/Renal (MED 622)
IS-GERD (MED 642)
Infection and Immunity (HS607) (MSMHS program)
I have recently shifted my research focus to the RWDD4 protein, which has an unknown
function. My lab is examining the protein and its predicted interactions with several
other proteins. Findings may further our knowledge of processes involved in programmed
cell dear, neuronal degeneration, and/or oncogenic processes.
Current and past student researchers in the lab:
Daisy Chan, MS; TUCOM Class of 2020
Angadpreet Sidhu, MS; TUCOM Class of 2019
Amrita Mahesh, MS; TUCOM Class of 2018
Emily Simon, MS; TUCOM Class of 2017
Trista Fuchs, MPH; TUCOM Class of 2017
Laura Marshal, MPH; TUCOM Class of 2017
Jeff Chiu, MS TUCOM Class of 2016
Mohammad Obaidullah, MS; TUCOM Class of 2017
Grants and Fellowships
Completed:
2011 PI, Intramural Research Project Proposal: Role of CASPASE-12 in African-Americans with systemic lupus erythematosus (Direct costs $10,000). G. Brinkley and L.A. Russell, co-PIs. Touro University-CA.
2011 PI, Intramural Research Project Proposal: Role of Caspase-12 in African-Americans with systemic lupus erythematosus (Direct costs $10,000). G. Brinkley and L.A. Russell, co-PIs. Touro University-CA. In progress through 6/30/12
2011 Co-PI Intramural Pilot Project Grant: Examination of altered monocarboxylate transporter expression in HD transgenic mice. (Direct costs $3,000). Gloria Klapstein, PI. Touro University-CA.
2010 Co-PI COHS Pilot Project Grant: Role of Caspase-12 genes in African-Americans with rheumatoid arthritis. Kevin Klapstein, Co-PI (Direct costs $3000). Touro University-CA, Vallejo, CA
2010 Co-PI COHS Pilot Project Grant: Role of Caspase-12 genes in African-Americans with rheumatoid arthritis. Kevin Klapstein, Co-PI (Direct costs $3000). Touro University-CA, Vallejo, CA
2009 Collaborator, R21 NS066469, Assay development for high affinity non-peptide HIV-1 gp41 inhibitors (Direct costs $100,000). NIH-ADDT Miriam Gochin, Co-PI. Touro University-CA, Vallejo, CA.
2009 Collaborator, R21 NS066469,Assay development for high affinity non-peptide HIV-1 gp41 inhibitors (Direct costs $100,000). NIH-ADDT Miriam Gochin, Co-PI. Touro University-CA, Vallejo, CA.
E. Hermel. Caspase-12 and lupus: the curious case of the dog that didn’t bark. 2016. Inflammation & Cell Signaling. e3:1383.
E. Hermel. Caspase-12, rheumatoid arthritis, and the dog that didn’t bark. 2016. Immunogenetics Online Access,1:1-3
T. Fuchs, J.A. Kelly, E. Simon, K. L. Sivils and E. Hermel. The anti-inflammatory CASPASE-12 gene does not influence SLE phenotype in African-Americans. 2016. Immunology Letters173: 21–25
L. Marshall, M. Obaidullah, T. Fuchs, N.S. Fineberg, G. Brinkley, T.R. Mikuls, S. L. Bridges Jr. and E. Hermel. 2014. CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics 66:281-5
M. Yavari, K.D. Klapstein, W.C. Hartwig, R. Rao, and E. Hermel. 2012. Identification of the functional caspase-12 allele in Indian subpopulations. Int. J. Immunogenetics. 39:389-93
E. Hermel and K.D. Klapstein. 2011. A possible mechanism for maintenance of the deleterious allele of human CASPASE-12. Med. Hypotheses 77:803–806
G. Zhou, D. Wu, E. Balogh, E. Hermel and M. Gochin. 2010. Design, synthesis and evaluation of indole compounds as novel inhibitors targeting gp41. Bioorg. Med. Chem. Lett.20:1500-1503.
J.E. Young, L. Gouw, S. Propp, B.L. Sopher, J. Taylor, A. Lin, E. Hermel, A. Logvinova, S.F. Chen, S. Chen, D.E. Bredesen, R. Truant, L.J. Ptacek, A.R. La Spada, and L.M. Ellerby. 2007. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. J. Biol. Chem. 282:30150-60.
E. Hermel, A.J. Hart, I. Gunduz, H. Acton, C. Kim, M. Wurth, S. Uddin, C. Smith, K. Fischer Lindahl and C.J. Aldrich. 2004. Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics. 56:639-49.
J. Gafni, E. Hermel, J. Young, C.L. Wellington, R. Siman, M.R. Hayden and L.M. Ellerby. 2004. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. J. Biol. Chem. 279:20211-20.
E. Hermel, J.Gafni, S.S. Propp, B.R. Leavitt, C.L. Wellington, J.E. Young, A.S. Hackam, A.V. Logvinova, A.L. Peel, S.F. Chen, V. Hook, R. Singaraja, S.Krajewski, P.C. Goldsmith, H.M. Ellerby, G.S. Salvesen, M.R. Hayden, D.E. Bredesen, and L.M. Ellerby. 2004. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington’s disease. Cell Death Differentiation. 11:424-438.
R.V. Rao, A. Peel, A. Logvinova, G. del Rio, E. Hermel, T. Yokota, P.C. Goldsmith, L.M. Ellerby, H.M. Ellerby and D.E. Bredesen. 2002. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Letters 25777:1-7.
T. Chun, E. Hermel, H. R. Gaskins, and C.J. Aldrich. 2001. CTL and cDNA sequence analyses of the MHC class Ib molecule Qa1 in nonobese diabetic (NOD) mice. Immunogenetics. 53:506-510.
R. Rao, E. Hermel, S. Castro-Obregon, A. Logvinova, G. Del Rio, L. M. Ellerby, P.C. Goldsmith, H.M. Ellerby and D.E. Bredesen. 2001. Coupling endoplasmic reticulum stress to the cell death program: mechanism of caspase activation. J. Biol. Chem. 276:33869-74.
E. Hermel, C. Smith and C.J. Aldrich. 2000. Allogeneic responses to the class Ib antigen Qa1:
limited TcR Vα but not Vβ chain usage. Immunogenetics. 51:600-605.E. Hermel, A. Hart, R. Miller and C.J. Aldrich. 1999. CTL and sequence analysis of MHC class
IB antigens Qa1c (H2-T23r) and Qa1d (H2-T23f). Immunogenetics. 49:712-717.
E. Hermel, M. Han, B. Hague, T. Kindt and J.J. Monaco. 1999. Isolation and mapping of the
DM genes of rabbit. Implications for the evolution of the DM family. Immunogenetics. 49:295-302.
T. Chun, E. Hermel, C.J. Aldrich and H. R. Gaskins. 1999. Porcine LMP7 proteasome subunit cDNA cloning and expression analysis. Immunogenetics. 49:72-77.
E. Hermel, E. Grigorenko and C.J. Aldrich. 1997. Increased class Ib antigen display on Tap-2 mutant cells by a mitochondrial function inhibitor. Cell. Immunology. 178:10-15Kasai, M., K. Hirokawa, K.-I. Kajino, K. Ogasawara, M. Tatsumi, E. Hermel, J.J. Monaco and T. Mizuochi. 1996. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur J Immunol. 26:2101-2107.
E. Hermel, J. Yuan and J.J. Monaco. 1995. Characterization of polymorphism within the H2-M MHC class II loci. Immunogenetics. 42:136-142.
E. Hermel and J.J. Monaco. 1995. RT1.DMa and RT1.DMb, the rat homologues of H2‑DMa and H2-DMb. Immunogenetics. 42:446-447.
E. Hermel, P. Robinson, J.-X. She and K. Fischer Lindahl. 1993. Sequence divergence of β2-microglobulin alleles of wild Mus musculus and Mus spretus implies positive selection. Immunogenetics. 38:106-116.
M. Attaya, S. Jameson, C.K. Martinez, E. Hermel, C. Aldrich, J. Forman, K. Fischer Lindahl, M.J. Bevan & J.J. Monaco. 1992 Ham-2 corrects the class I antigen processing defect in RMA-S cells. Nature. 355:647-649.
C.J. Aldrich, R. Waltrip, E. Hermel, M. Attaya, K. Fischer Lindahl, J.J. Monaco and J. Forman. 1992. Cytotoxic T lymphocyte recognition of Qa1b antigens on target cells lacking a functional Tap-2 transporter. J. Immunol. 149:3773.-3777.
J.D. Davis, D.H Wilson, E. Hermel, G. Butcher, K. Fischer Lindahl & D.B. Wilson. 1991. Generation of T cells with lytic specificity for atypical antigens. I. A mitochondrial antigen in the rat. J. Exp. Med. 173:823-832.
K. Fischer Lindahl, E. Hermel, B.E. Loveland and C.-R. Wang. 1991. The maternally transmitted antigen: A model minor antigen. Annu. Rev. Immunol. 9:351-372.
E. Hermel, E. Grigorenko and K. Fischer Lindahl. 1991. Expression of medial class I histocompatibility antigens on RMA-S mutant cells. Int. Immunol. 3:407-412.
C.-R. Wang, A. Livingstone, J. Howard, G. Butcher, E. Hermel and K. Fischer Lindahl. 1991. Antigen presentation by neo-classical MHC class I gene products in murine rodents. NATO ASI Series, Vol. H59: Molecular Evolution of the Major Histocompatibility Complex. J. Klein and D. Klein, eds. Springer-Verlag, Berlin. pp 441-462.
B. Loveland, C.-R. Wang, H. Yonekawa, E.Hermel, and K. Fischer Lindahl. 1990. Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein. Cell. 60:971-980.
J.D. Davis, D.H. Wilson, E. Hermel, G. Butcher, K. Fischer Lindahl and D.B. Wilson. 1990. A maternally-transmitted antigen system in the rat. Transpl. Proc. 22:2547-2548.
K. Fischer Lindahl, E. Hermel, B.E. Loveland, S. Richards, C.-R. Wang, and H. Yonekawa. 1989. Molecular definition of a mitochondrially encoded mouse minor histocompatibility antigen. Cold Spring Harbor Symp. Quant. Biol. 56:563-569.
Current TUCOM and University Committees:
8/13-date Member, TU-CA Faculty Grievance Committee
5/13-date Member, MSMHS Admissions Committee
4/12-date Member TU-CA Research Committee
11/00-date Member, TUCOM Admissions Committee
Extramural Service:
12/16 Ad hoc reviewer for Cancer Biomarkers
2013-date Ad hoc reviewer for Medical Hypotheses
2015-date Ad hoc reviewer for Evidence-Based Complementary and Alternative Medicine
2/2015-date Seed Grant Reviewer, Touro UniversitySystem Intramural Grant Program
10/2014-date Member, Science Advisory Board
2/2010-date External Reviewer for AOA Research Grant and Abstract Proposals
Awards and Honors
2008 Faculty Speaker, Class of 2008 Graduation
2008 Teacher of the Year Award, Class of 2008
2001 Faculty Service Award in Clinical Education
2000 Best Use of Case Studies Teaching Award
2000 Golden Lasso Faculty Unity Award
1992 Sigma Xi Graduate Student Research Forum Award
Positions:
7/2011-present Professor of Basic Science, Touro University College of Osteopathic Medicine, Vallejo, CA
7/2002-6/2011 Associate Professor of Basic Science, Touro University College of Osteopathic Medicine, Vallejo, CA
1/2000-12/2005 Visiting Scholar, Buck Institute for Age Research, Novato, CA
7/1999-6/2002 Assistant Professor of Basic Science, Touro University College of Osteopathic Medicine, Vallejo, CA
2/1997-5/1999 Assistant Scientist, Department of Microbiology and Immunology, Indiana University School of Medicine, Evansville Center, Evansville, IN
11/1992-2/1997 Postdoctoral Fellow, Department of Molecular Genetics, University of Cincinnati, Cincinnati, OH (Dr. J.J. Monaco, advisor)
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