Faculty & Staff at TUC
Department: Basic Sciences, MSMHS
Phone: (707) 638-5235
Fax: (707) 638-5255
Office: Administration & Faculty 1, Rm. 135
|Institution||Degree||Field of Study||Obtained|
|University of California, Irivine||Ph.D.||Physiology/Biophysics||1992|
|New York Unversity||M.S.||Physics||1986|
Fall Semester: Neurophysiology (DO program and MSMHS program), Cardiovascular Physiology (MSMHS program)
Spring Semester: Cardiovascular Physiology (DO program), Renal Physiology (DO program). Cardiovascular Physiology (PA program)
The research in my laboratory focuses on the voltage-gated potassium channel HERG (Human-ether-a-go-go related gene) which is responsible for the repolarization of the cardiac action potential in cardiac myocytes. Reduction of HERG channel numbers by a variety of different mechanisms including block by pharmaceutical agents or a number of extracellular electrolytes, as well as mutations in the gene encoding the HERG channel, can cause long QT syndrome. In some rare cases long QT syndrome can degenerate into ventricular fibrillation which can be lethal.
The research focuses on studying:
- the mechanisms by which a number of different drugs block HERG
- the effects of extracellular electrolytes (such as calcium, magnesium, and hydrogen) on the HERG channel
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