Education

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Employment History

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Teaching

TCOM/University of North Texas Health Science Center (Director/Co-Director)


2002 - present Associate Dean for Clinical Research

1984-86 Director, Internal Medicine Residency Program, Texas College of Osteopathic Medicine

1982-86 Course Director, Internal Medicine Clinical Clerkship

1982-84 Director, Internal Medicine Residency Program, Fort Worth Osteopathic Medical Center

1982-84 Course Director, Internal Medicine Course

1981 Course Co-Director Problem Solving Course

1980 Course Co-Director Medicine/Surgery Course

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Honors & Awards

2006 Texas College of Osteopathic Medicine Yearbook Dedication

2005 Gutensohn-Denslow Award

2005 Top Doctors in Tarrant County in Internal Medicine- Fort Worth Magazine

2004 Darryl A. Beehler, DO Research Mentor of the Year Award

2003 American Osteopathic Foundation’s Astra-Zeneca Healthy Heart Award

2003 Top Doctors in Tarrant County in Internal Medicine-Fort Worth Magazine

2002- Osteopathic Heritage Foundation Distinguished Chair in Clinical Research
1999 President’s Citation
Chicago College of Osteopathic Medicine

1997 Internist of the Year
American College of Osteopathic Internists

1995 Outstanding Achievement Award
Chicago College of Osteopathic Medicine Alumni Association

1988 Fellow, American College of Osteopathic Internists

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Publications

Publications – Journals

Clearfield MB, Amerena J, Bassand JP, Hernandez-Garcia HR, Miller SS, Sosef FM, Palmer MK, Bryzinski BS. Comparison of the efficacy and safety of rosuvastatin 10 mg and atorvastatin 20 mg in high risk patients with hypercholesterolemia-Prospective study to evaluate the Use of Low doses of the Statins Atorvastatin and Rosuvastatin (PULSAR) Trials 2006;7:35 doi:1186/1745-6215-7-35

Clearfield M. Statins and the Primary Prevention of Cardiovascular Disease. Current Atherosclerosis Reports. 2006;8:390-396

Alexander J, Clearfield M. Cardiovascular disease after menopause: a growing epidemic. Minerva Ginecologica 2006;58:35-40.

Clearfield M. Clinical Trials Report
Current Atherosclerosis Reports 2006;8:7-12.

Clearfield M, Downs JR, Lee M, Langendorfer A, McConathy W, Gotto AM. Implications from the Air Force/Texas Atherosclerosis Prevention Study for the Adult Treatment Panel III Guidelines American Journal of Cardiology 2005;96:1674-1680

Yurvati AO, Carnes M, Clearfield M, Stoll S, McConathy WJ. Hemodynamic effects of Osteopathic Manipulative Treatment immediately after coronary bypass surgery. Journal of the American Osteopathic Association 2005;105:475-481

Clearfield M. C-Reactive Protein: A New Risk Assessment Tool for Cardiovascular Disease. Journal of the American Osteopathic Association 2005;105:409-416.

Cholesterol Treatment Trialists (CTT) Efficacy and safety of cholesterol lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomized trial of statins. Lancet 2005;366:1267-1278.

Clearfield M. Clinical Trials Report
Current Atherosclerosis Reports 2005;7(1):7-10.

Clearfield MB. The Future looks promising for the Treatment of Patients with Coronary Heart Disease. Journal of the American Osteopathic Association 2004;9:51-52

Clearfield M. Coronary Heart Disease Risk Reduction in Postmenopausal Women: The Role of Statin Therapy and Hormone Replacement Therapy
Preventive Cardiology 2004;7:131-136

Girman CJ, Rhodes T, Mercuri M, Pyorala K, Pederson TR, Beere PA, Gotto AM, Clearfield M. The Metabolic Syndrome and Risk of Major Coronary Events in the Scandinavian Simvastatin Survival Study and the Air Force/Texas Coronary Atherosclerosis Prevention Study.
American Journal of Cardiology 2004;93:136-141.

Clearfield M. Future Directions in Dyslipidemia Management. John’s Hopkins University Advanced Studies in Medicine. 2004;4(1B):S53-S60.

Clearfield M. Evolution of cholesterol management therapies: Exploiting potential for further improvement. American Journal of Therapeutics 2003;Jul-Aug;10(4):275-281.

Clearfield MB. A novel therapeutic approach to dyslipidemia.
Journal American Osteopathic Association 2003;103(1):S16-S20.

Clearfield MB. The National Cholesterol Education Program Adult Treatment Panel III Guidelines. Journal American Osteopathic Association 2003;103(1):S1-4.

Clearfield MB. Under-identification and under-treatment of dyslipidemia. Journal American Osteopathic Association 2003;103(1):S5-8.

Clearfield MB, Weis SE, Willis JM, Vasenius KA, McConathy WJ. Lablility of serum low-density lipoprotein cholesterol during screening of Air Force/Texas Coronary Atherosclerosis Prevention Study (ACAPS/TexCAPS) cohort. Journal American Osteopathic Association 2002;102(7):377-384.

Ridker PM, Shih J, Cook TJ, Clearfield MB, Downs JR, Pradhan AD, Weis SE, Gotto AM. Plasma Homocysteine Concentration, Statin Therapy, and the Risk of First Acute Coronary Events. Circulation 2002;105:1776-1179.

Clearfield M Adult Treatment Panel III: Do we need another set of Cholesterol Guidelines. Journal American Osteopathic Association 2002;102(5):S6-11.

Clearfield M. Statins: Balancing benefits, efficacy and safety.
Expert Opinion on Pharmacology. 2002;3(5):469-477.

Clearfield M, Downs JR, Weis S, Whitney EJ, Kruyer W, Shapiro D, Stein E, Langendorfer A. Beere PA, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study: Efficacy and Tolerability of Long-Term Treatment with Lovastatin in Women.
Journal of Women’s Health & Gender Based Medicine. 2001;10(10):1-11.

.Ridker PM, Rifai N, Clearfield M, Downs JR, Weis SE, Miles SJ, Gotto AM. Measurement of C-Reactive Protein for the Targeting of Statin Therapy in the Primary Prevention of Acute Coronary Events. New England Journal of Medicine. 2001;344(26):1959-1965.

Clearfield M. New Guidelines for the new millennium.
Journal American Osteopathic Association 2001;101(6):355,363.

Downs JR, Clearfield M, Tyroler A, Whitney EJ, Kruyer W, Langendorfer A, Zagrebelsky,
Shapiro D, Beere PA, Gotto Am. Air Force/Texas Coroanry Atherosclerosis Prevention Study
(AFCAPS/TexCAPS): Additional Perspectives on Tolerability of Long-Term Treatment with
Lovastatin. American Journal of Cardiology 2001:87:1074-1079.

Gotto AM, Whitney E, Stein E, Shapiro DR, Clearfield M, Weis S, Jou J, Langendorfer A, Beere P, Watson D, Downs JR, de Cani J. Relation Between Baseline and On-Treatment Lipid parameters and First Acute Major Coronary Event in the Air Force/Texas Coronary Atherosclerosis Prevention Study. Circulation. 2000;101:477-484.

Osborn GG, Meoli FG, Buser BR, Clearfield MB, Bruno JP, Sumner-Truax L. The Comprehensive Osteopathic Medical Licensing Examination, COMLEX-USA:A new paradigm in testing and evaluation. Journal American Osteopathic Association. 2000;100:105-111.

Clearfield M, Whitney EJ, Weis S, Downs JR, Shapiro DR, Stein EA, Watson DJ, Langendorfer A, Beere PA, Stamler J, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): Baseline characteristics and comparison with USA population.
Journal of Cardiovascular Risk 2000;7:125-133.

Shores JH, Clearfield M, Alexander J. An Index of Students Satisfaction with Instruction. Academic Medicine. 2000;75(10):S106-108.

Gotto Am, Boccuzzi SJ, Cook JR, Alexander CM, Roehm JB, Meyer GS, Clearfield MB, Weis S, Whitney E. Effect of Lovastatin on Cardiovascular Resource Utilization and Costs in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS).
American Journal of Cardiology 2000;86:1176-1181.

Mathe AJ, Clearfield MB. Long-term therapy of coronary artery disease: a vascular biology perspective. Journal American Osteopathic Association 2000;100(11):S13-16.

Jones P, Kafoneh S, Laurera I, Hunninghake D, Curves Investigators. Comparative dose efficacy study of Atorvastatin versus Simvastatin, Pravastatin, Lovastatin and Fluvastatin in patients with hypercholesterolemia (Curves Study).
American Journal of Cardiology. 1998;81(5):582-587.

Lacko AG, Kudchodkar BJ, Loney WW, Clearfield MB, Weis S. Decrease in high density lipoprotein cholesterol (HDL-C) levels following Gemfibrozil therapy.
Clinical Chemistry Laboratory Medicine 1998;36(6):389-92.

Downs JR, Clearfield MB, Weis S, Whitney E, Shapiro DR, Beere PA, Langendorfer A, Stein EA, Kruyer MD, Gotto AM. Primary prevention of acute coronary events with Lovastatin in men and women with average cholesterol levels results of AFCAPS/TexCAPS.
Journal American Medical Association. 1998;279:1615-1622.

Loney WW, Kudchodkar BJ, Weis SE, Clearfield MB, Shores J, Lacko AG. Evaluation of gemfibrozil therapy: predictive response from lipoprotein subfraction analysis. American Journal of Therapeutics.1997; 4:301-9.

Shen L, Cavaleri T, Clearfield M, Smoley J. Comparing medical knowledge of osteopathic medical trainees in DO and MD programs: a random effect meta-analysis.
Journal of the American Osteopathic Association. 1997;97(6):359-362.

Downs JR, Beere PA, Whitney E, Clearfield M, Weis S, Rochen J, Stein EA, Shapiro D, Langendörfer A, Gotto AM. Design and rationale of the Air Force/Texas coronary atherosclerosis prevention study (AFCAPS/TEXCAPS).
American Journal of Cardiology. 1997;80:287-93..

Cholesterol Treatment Trialists (CTT) Collaboration. Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens.
Amercian Journal Cardiology. 1995;75:1130-1134.

Knebl J, DeFazio P, Clearfield MB, Little L, McConathy WJ, McPherson R, Lacko AG. Plasma lipids and cholesterol esterification in Alzheimer's disease. Mechanisms of Aging and Dev. 1994;73:69-77.

Clearfield MB, Lee N, Armstrong L, DeFazio P, Kudchodkar BJ, Lacko AG. The effect of Captopril on the oxidation of low density lipoproteins (LDL) in vitro. Pharmacology and Toxicology. 1994;75:218-221.

Clearfield MB, Wood HS, Vasenius KA. Risk factors other than hypertension and dyslipidemia to be considered in preventive cardiology.
Journal of Osteopathic Medicine. 1993;14-31.

Clearfield MB. Current management approaches to hyperlipidemia.
Journal of the American Osteopathic Association. 1993(11suppl):1207-1211.

Clearfield MB. Therapeutic implications for dyslipidemia.
Journal of Osteopathic Medicine. 1992;(August):46-50.

Weis S, Clearfield MB, Kudchodkar B, Lacko A. The efficacy of Gemfibrozil therapy for raising high density lipoprotein levels in hypertriglyceridemic patients. Artery 1992;19(6):353-367.

Lacko AG, Clearfield MB, Weis SE. The role of high density lipoproteins in determining coronary risk. Tarrant County Physician. March, 1992.

Kudchodkar BJ, Weis SE, Clearfield MB, Lacko AG. Factors influencing plasma high density cholesterol (HDL-C) levels upon treatment (Rx) with gemfibrozil. Arteriosclerosis 1991;(suppl).November.

Clearfield MB. The role of dyslipidemia in preventive cardiology.
Osteopathic Medical News, 1991;8(7):August.

Clearfield MB. The role of hypertension in preventive cardiology. Part 2.
Osteopathic Medical News, 1990;7(8):August.

Clearfield MB. The role of hypertension in preventive cardiology. Part 1.
Osteopathic Medical News, 1990;7(7):July.

Clearfield MB, Fedorko S, McKinney ME. Physician awareness of elevated cholesterol. Journal of the American Osteopathic Association, 1990; 90:February.

Clearfield MB. Meperidine hydrochloride induced hypereosinophilia,
Journal of the American Osteopathic Association, 1987;87, September.

Clearfield MB, Trinkle PL. Hypokalemic subclinical neuromyopathy,
Journal of the American Osteopathic Association, 1986;86, December.

Trinkle PL, Clearfield MB. Primary hyperaldosteronism,
Journal of the American Osteopathic Association, 1983;83, November.

Duberstein DL, Efrusy ME, Clearfield MB, Lombardo PR. Primary sclerosing cholangitis and cholangiocarcinoma: report of two cases,
Journal of the American Osteopathic Association, Vol. 1978;77:March.

Publications – Abstracts, Editorials, Book Chapters

Chapters/Reviews/Books

Weis S, Clearfield M, Downs J, Gotto A. The Air Force/Texas Coronary Atherosclerosis Prevention Study: Primary Prevention of Acute Major Coronary Events in Women and Men with Average Cholesterol. Cholesterol-Lowering Therapy-Evaluation of Clinical Trial Evidence. Edited by Scott Grundy. Marcel Dekker Inc. 151-172, 2000.

Book Review: Clearfield MB. Review of General Internal Medicine: A Self-Assessment Manual, Journal of the American Osteopathic Association, 1983.

Abstracts
Cui Y, Clearfield M. Non-High Density Lipoprotein Cholesterol is better than LDL-C in Explaining the Reduction in First Acute Major Coronary Events with Statin Therapy: A Secondary Analysis of the Air Force/Texas Coronary Atherosclerosis Prevention Study
ACC Epidemiology and Prevention 2007 Abstract Number 560

Clearfield M, Kallend D, Palmer M, Sosef F for the PULSAR study investigators. Efficacy and Safety of Rosuvastatin 10 mg versus Atorvastatin 20 mg: Results of the PULSAR study. Atherosclerosis 2005;6:104(W16-P-014).

Yurvati A, Carnes M, Clearfield M, Stoll S, McConathy W. Hemodynamic Effects of Osteopathic Manipulative Treatment Immediately Following Coronary Artery Bypass Surgery. JAOA 2003;103(8):381 P11

Clearfield M, Gotto AM, Downs JR, Nag SS, Jiandong L, Alexander CM, Cook TJ, Beere PA, Langendorfer A. Impact of Insulin Resistance on Acute Major Coronary Events in the Air Force/Texas Coronary Atherosclerosis Prevention Study.
Diabetes;2002:Vol 51, suppl 2:pg 1A-738 # 627P.

Clearfield M. Overview of the Safety of Statin Treatment: An Update on Rosuvastatin. American Society of Hospital Pharmacists. Atlanta Ga. 12/02

Gotto AM, Downs JR, Clearfield M, Weis S, Kruyer W, Whitney E, Stein EA. Follow-up of the Air Force/Texas Coronary Atherosclerosis Prevention Study Cohort:Persistent Benefit with Lovastatin Treatment. American Heart Association 74th Scientific Session, Anaheim Cal 11/01

Ridker PM, Rifai N, Miles JS, Downs JR, Clearfield M, Gotto Am, Cook TJ, Weis S, Langendorfer A, Beere PA. Relation Between Baseline Homocysteine Levels and Risk of Acute Major Coronary Events in the Air Force/Texas Coronary Atherosclerosis Prevention Study. American Heart Association 74th Scientific Session, Anaheim Cal 11/01

Clearfield MB, Weis SE, Weiss M, McConathy WM. Hyporesponse to Lovastatin in the Texas Coronary Atherosclerosis Prevention Study (TexCAPS) Cohort.
UNTHSC Research Appreciation Day 3/01

Shores JH, Clearfield M, Alexander J. An Index of Students Satisfaction with Instruction. American Association of Medical Colleges, Research in Medical Education Conference. Chicago Ill. 11/00.

Ridker PM, Rifai, Miles JS, Downs JR, Clearfield M, Gotto AM, Cookd TJ, Langendorfer A, Beere PA. Lovastatin 20-40 mg/day Lowers High Sensitivity C-Reactive Protein Levels in AFCAPS/TexCAPS.
American Heart Association 73rd Scientific Session, New Orleans, La. 11/00.

Ridker PM, Rifai N, Downs JR, Clearfield M, Gotto AM, Cook TJ, Langendorfer A. Beere PA. Relation between baseline C-reactive protein levels and risk of acute major coronary events in the Air Force/Texas Coronary Atherosclerosis Prevention Study. XXII Congress of the European Society of Cardiology. Netherlands. European Heart Journal. 21:496, #2728, 8/00.

Gotto AM. Beere PA, Allen SE, Cook JR, Downs JR, Clearfield M, Weis S Langenorfer A. Air Force/Texas Atherosclerosis Prevention Study (AFCAPS/TexCAPS)- Benefits of Lovastatin Treatment in Risk Subgroups Defined by Framingham Risk Equations. American College of Cardiology 49th Scientific Session. Anaheim California, J American Coll Cardio 35:313A, 2000.

Kruyer WB, Zagrebelsky V, Whitney EJ, Qinfen Y, Langerdorfer A Beere PA, Shapiiro Farmer J, Downs JR, Clearfield M, Weis, Gotto AM. Air Force/Texas Atherosclerosis Prevention Study (AFCAPS/TexCAPS) –The Effect of Treatment with Lovastatin on the Utilization of Invasive Cardiac Procedures and the Extent of Angiographic Disease. American College of Cardiology 49th Scientific Session. Anaheim California, J Americ Coll Cardio 35:325A, 2000.

Gotto AM, Stein EA, Downs JR, Clearfield MB, Weis S, Whitney EJ, Beere PA, Shapiro DR. Air Force/Texas Coronary Athreosclerosis Prevention Study (AFCAPS/TexCAPS):Relation of Risk to Baseline Non-HDL Cholesterol. American Heart Association 72nd Scientific Session. Atlanta, Ga. Circulation Supp I,100(18), I-197, #1017, 1999.

Gotto AM, Whiteny EJ, Stein EA, Shapiro DR, Clearfield MB, Weis SA, Beere PA, Watson DJ, Downs JR, de Cani JS. Air Force/Texas Coronary Atherosclerosis Prevention Study: Relative Benefitof Primary Prevention in Subgroups with Different Absolute Risk According to US NCEP ATP II and Joint European Guidelines. XXI Congress of the European Society of Cardiology. Barcelona, Spain. European Heart J, 20:473 (Supp #2495) Aug-Sept 1999.

Kruyer WB, Zagrebelsky V, Farmer J, Yu Q, Downs JR, Clearfield MB, Weis S, Whiteny E, Shapiro DR, Beere PA, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study: Invasive Procedures and Extent of Disease. XXI Congress of the European Society of Cardiology. Barcelona, Spain. European Heart J, 20;238(Supp #1304) Aug-Sept 1999.

Stein E, Weis S, Downs JR, Clearfield M, Whitney E, Beere P, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study:Risk reduction by LDL-C and HDL-C tertiles. European Atherosclerosis Society. 5/99.

Downs JR, Beere PA, Clearfield MB, Weis S, Whitney EJ, Shapiro DR, Kruyer WB, Watson DJ, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study: Lipid Modification and Risk Associated with Non-Lipid Risk Factors. American College of Cardiology. New Orleans, J Amer Coll Cardio, 33:244A, 1999.

Gotto AM, Whitney EJ, Stein EA, Shapiro DR, Clearfield MB, Weis S, Watson DJ, Cook JR, Beere PA, Downs JR. Predicting Risk of First Acute Major Coronary Events (AMCEs) in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). American College of Cardiology. New Orleans, J Amer Coll Cardio, 33:263A, 1999.

Clearfield MB, Stein EA, Downs JR, Weis S, Whitney EJ, Shapiro DR, Beere PA, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study: Risk Reduction by NCEP LDL-C Cutpoints. American Heart Association 71st Scientific Session. Circulation 1998 Oct 27;98(17 suppl):I-46.

Downs JR, Clearfield MB, Weis S, Whitney EJ, Shapiro DR, Beere PA, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study: Primary Prevention of Coronary Heart Disease in Women. American Heart Association 71st Scientific Session. Circulation 1998 Oct 27;98(17 suppl):I-46.

Whitney EJ, Downs JR, Clearfield MB, Weis S, Stein EA, Shapiro DR, Beere PA, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention Study: Extending the Benefit of Primary Prevention to Healthy Elderly Men and Women. American Heart Association 71st Scientific Session. Circulation 1998 Oct 27;98(17 suppl):I-46.

Downs JR, Clearfield MB, Weis SE, Kruyer WB, Whitney EA, Stein EA, Shapiro DR, Beere PA, Gotto AM. Final results of the AFCAPS/TexCAPS coronary atherosclerosis prevention study. American College of Cardiology Annual Scientific Session. Atlanta, GA, J American Coll Cardio 31:280A, 1998.

Jones P. On Behalf of the Curves Investigators. Comparison of the dose efficacy of atorvastatin with pravastatin, simvastatin, fluvastatin, and lovastatin. XIX Congress of the European Society of Cardiology. 8/97.

Whitney EA, Clearfield MB, Downs JR, Shapiro DR, Stein EA, Beere PA, Gotto AM. Air Force/Texas Coronary Atherosclerotic Prevention Study: Design and Baseline Characteristics. American College of Cardiology. J American Coll Cardio 29: (2a):349A, 1997.

Downs JR, Beere PA, Whitney E, Clearfield MB, Weis S, Rochen J, Stein EA, Shapiro DR, Langendorfer A, Gotto AM. Air Force/Texas Coronary Atherosclerosis Prevention (AFCAPS/TexCaps): Benefits and Rationale. Society of Air Force Physicians. 3/97.

Ward JM, Clearfield MB, McConathy WJ, Spellman CW. Pseudo-myelomas: elevated total serum proteins associated with hypertriglyceridemia. American College of Osteopathic Internists. 11/96.

McConathy WJ, Bousted S, Kudchodkar BJ, Nair M, Brett P, Clearfield MB, Lacko AG. Interaction of LCAT and apolipoprotein D. International Symposium on the Role of HDL in Disease Prevention. 11/96.

Pertusi RM, McConathy WJ, Chen MD, Lane DM, Weis SE, Clearfield MB, Lacko AG. High frequency autoantibodies to phosphatyl serine in hyperlipidemia. 38th Annual AOA Research Conference, 1994.

McConathy WJ, Chen Z, Pertusi RM, Lane DM, Weis SE, Clearfield MB, Lacko AG. High frequency of autoantibodies to phosphatides. Seminar in Hypertension, UNTHSC Research Appreciation Day, 3/94.

Clearfield MB, Weis SE, Fehl LM, Vasenius KA, Whitney E, Rochen J, Armstrong P, Fellows M, Downs JR. TexCaps: the First Year's Experience. AOA Research Conference. Boston, 10/93.

Knebl J, DeFazio P, Clearfield MB, Little L, McConathy WJ, McPherson R, Lacko AG. Plasma lipids and cholesterol esterification in Alzheimer's disease. Proc 62nd EAS Congress. Jerusalem, Israel, 1993.

McConathy WJ, Chen Z, Weis SE, Clearfield MB, Lacko AG. Increased incidence of autoantibodies to phospholipids in hyperlipoprotenemia. 66th Annual Meeting, American Heart Association. p. 108, 1993.

Lacko AG, McPherson R, Weis SE, Clearfield MB, Kudchodkar BJ. Plasma lecithin: cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) as determinants of changes in high density lipoprotein cholesterol (HDL-C) levels. Proc 2nd International Symposium on High Density Lipoproteins. San Antonio, 2/92.

Kudchodkar BJ, Weis SE, Clearfield MB, Lacko AG. Factors influencing high density lipoprotein cholesterol (HDL-C) levels. Proc 2nd International Symposium on High Density Lipoproteins. San Antonio, 2/92.

Clearfield MB, Weis S, Kudchodkar BJ, Lacko AG. Factors influencing the increase in high density lipoprotein cholesterol (HDL-C) by Gemfibrozil. ACOI Research Conference. Boston, Mass, 10/91.

Weis S, Clearfield MB, Kudchodkar BJ, Lacko AG. Therapeutic efficacy of Gemfibrozil for raising HDL cholesterol based on post-treatment triglyceride levels. AOA Research Conference, 10/91. JAOA 91: 1032, 10/91.

Clearfield MB, Kudchodkar BJ, Weis SE, Lacko AG. The effects of Gemfibrozil on the parameters of reverse cholesterol transport. Proc Nat Conf on Cholesterol and High Blood Pressure Control. Washington, D.C., 5/91.

Clearfield MB, Kudchodkar BJ, Weis S, Lacko AG. The Effects of Gemfibrozil on the Parameters of Reverse Cholesterol Transport. National Conference on Cholesterol and High Blood Pressure Control. Washington, D.C., 4/91.

Clearfield MB, Fedorko S, McKinney ME. Osteopathic Medical Education: A Supportive Environment for Preventive Cardiology Curriculum, 2nd International Conference on Preventive Cardiology, 6/89

McKinney ME, Hofschire PJ, McIlvain HE, Fedorko S, Clearfield MB. Cardiovascular Reactivity to Mental Stress: Does it Predict the Development of Cardiovascular Disease? 2nd International Conference on Preventive Cardiology, Washington, D.C., 6/89.

Fedorko S, Clearfield MB, Physician Response to Hypercholesterolemia After Clinical Redefinition and Educational Program. Southwestern Psychological Association, Houston, Texas, 4/89.

Clearfield MB. Physician Awareness to Elevated Cholesterol, 1st National Cholesterol Meeting, Washington, D.C., 11/88

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Research Grants

Phase II Double Blinded Randomized Controlled Parallel Group Study evaluating the Efficacy and Safety of three doses of RO4607381 Combined with Pravastatin over a 12 week period in Patients with Low HDL-C
Principal Investigator
2005-06 Funded $90,331 Hoffman-LaRoche

Research, Education and Metabolic Studies (DREAMS)
Traditional and Emerging Risk Factors for Individuals Developing Diabetes, Metabolic Syndrome and Coronary Heart Disease. Project 2.
Principal Investigator
2004-2005 Funded $401,419 Centers for Disease Control and Prevention
2005-2006 Funded $365,435 Centers for Disease Control and Prevention

A 6 week Open label Randomized Multi-Center Phase IIIb Study to Compare Efficacy and Safety of Rosuvastatin 10 mg with Atorvastatin 20 mg in Subjects with Hypercholesterolemia and either a History of CHD or CHD Risk Equivalent (PULSAR)
Principal Investigator
2003-2004 Funded $28,000 Astra-Zeneca

A Randomized, Double Blind, Placebo –Controlled , Multicenter Phase III Study of Rosuvastatin 20 mg in the Primary Prevention of Cardiovascular Events Among Subjects with Low Levels of LDL-C and Elevated Levels of C-Reactive Protein. (JUPITER)
Principal Investigator.
2003-2006 Funded by Astra-Zeneca, $96,000

Hypo-Responders to Statins, UNTHSC Intramural Grant,
2000, Martin Weiss, D.O. Principal Investigator; $10,400.

A 24 week Randomized Double-blind Multicenter Trial to Evaluate the Efficacy and Safety of Starting and Maximum Doses of ZD4522 and Atorvostatin in the Treatment of Subjects with Hypercholesterolemia and documented Atherosclerosis
Principal Investigator;
1999 Funded by Astra-Zeneca, $46,600.

A Multi-Center, Randomized, Parallel Group 8 Week Comparative Dose Efficacy and Safety of Once Daily Atorvastatin with Other Statins. (CURVES).
Principal Investigator.
1996, Funded by Parke-Davis $42,000.

Atherosclerotic Risk Reduction and Atorvastatin.
1996 Funded by Parke-Davis. Principal Investigator, $42,000.

Texas Coronary Atherosclerosis Prevention Study. A Randomized Double-Blind, Placebo Controlled Trial of the Effect of Lovastatin on the Incidence of Primary Coronary Heart Disease in Patients with Mild to Moderate Elevations in Total and LDL Cholesterol in Combination with Low-HDL Cholesterol.
1992-1997, Funded by Merck Sharp and Dohme.
Principal Investigator, $6,400,000

Effect of Pravastatin on Continuing Hypercholesterolemia.
1991-1992 Funded by Bristol Meyer-Squibb. Co-Investigator. $12,000.

Educational Grant for Lipid Symposium.
1990, Funded by Merck, Sharp & Dohme, $5,000.

The Potential Protective Effect of Captopril Against the Deposition of Low Density Lipoprotein (LDL) Cholesterol in the Arteries",
1990 Funded by E.R. Squibb & Sons, Inc.,
Principal Investigator. $5,000

Educational Grant for Lipid Symposium.
1989, Funded by Merck, Sharp & Dohme, $5,000.

"Regulation of High Density Lipoprotein (HDL) Levels in Human Plasma. Stephen E. Weis, D.O., Principal Investigator, Michael B. Clearfield, D.O., Co-Investigator, 10% FTE 1989, AOA Research Grant #89-11-299, $14,000

"A Double-Blind Comparative Study of Prinomide vs. Naproxen vs. Placebo in Patients with Rheumatoid Arthritis",
1988 Funded by Ciba-Geigy Corporation, Bernard R. Rubin, D.O., Principal Investigator,
Michael Clearfield DO co-investigator, $27,990

"An Open-Label Study of Voltaren Treatment in Patients with Rheumatoid Arthritis Using Arthritis Impact Measurement Scales Protocol MCS #125A",
1987-88 Funded by Ciba-Geigy Corporation, Bernard R. Rubin, D.O., Principal Investigator, Michael B. Clearfield, D.O. co-investigator $6,000

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